Van de Ven Double Ends Everton's Unbeaten Streak at Brand New Stadium
The Dutch defender became the initial defender to net twice in a English top-flight game for Tottenham since the Belgian defender in March 2013.
At a glance
The Spurs defender nods home twice in first half
The home side's Jake O'Brien has equalizer ruled after VAR review
Pape Matar Sarr scores third in 89th minute
This loss is the Merseyside club's initial at Hill Dickinson Stadium
Micky van de Ven scored twice as Spurs prolonged their winning streak on the road in the top division and handed Everton their first defeat at their new home.
The Toffees were unbeaten in their five previous fixtures at their recently opened stadium at Bramley-Moore Dock, having departed Goodison Park behind after more than a century at the end of the previous campaign.
But Tottenham's leader the Dutchman pounced on two occasions from corners in the opening 45 minutes to put their impressive record at jeopardy, and they were unable to turn it around before Pape Matar Sarr - set up by former Toffees attacker the Brazilian - nodded in a third to put the game to bed.
Jake O'Brien thought he had levelled the scores five minutes after the defender's opener, directing a powerful header past Guglielmo Vicario from an set-piece.
Beto, meanwhile, failed to convert a number of opportunities, while Vicario made a succession of fine saves to ensure the London club went five away games unbeaten in the English top flight.
But the VAR intervened, advising the match official to check the score on the pitchside monitor and the referee decided that Jack Grealish and Iliman Ndiaye were in an illegal position and had interfered with the Tottenham goalkeeper.
This victory elevates Thomas Frank's side into third place in the division, five points off north London rivals and leaders Arsenal.
Everton remain in 14th position and are half a dozen points ahead of the relegation zone.
Tottenham analysis: Van de Ven fulfils role at each end of pitch
Following a uninspiring weekday display in the Champions League against Monaco, where they mustered a mere attempts on goal, Frank opted for Randal Kolo Muani in attack instead of ex-Everton forward the Brazilian.
The summer signing was unable to make much of an impact before being substituted for the substitute after an hour on the field, but it turns out he proved unnecessary in the final outcome.
Centre-back Van de Ven transformed into an attacking force to be reckoned with.
Tottenham's first goal came from a well-worked set-piece play, with the midfielder heading the ball back across the six-yard box for an free Van de Ven to score.
And Ven de Ven - filling in as captain in the Argentine's absence - added his second in first-half stoppage time as he outjumped Jordan Pickford to nod in.
Van de Ven was equally outstanding in defensive duties, partnering well with Kevin Danso as the pair handled superbly with the 34 crosses thrown their way by Everton.
Toffees breakdown: Everton missing striker's instinct
The club's new home had been a happy hunting ground, but it appears the novelty may have worn off slightly and fans flocked to the gates after Sarr's final goal for Tottenham.
The break in Everton's unbeaten home run will not be a major concern for David Moyes, but their attacking woes are.
The forward and the other striker - the Everton's pair of recognised centre-forwards - had scored just a single goal between them before the weekend's match.
And they were failed to add to that miserable tally on a wet and gloomy night on in Liverpool.
Beto's performance was summed up when he opted to overhead kick a clear chance from near the goal, even with having room and time to reposition for a simpler attempt that would have tested the keeper.
Barry, too, was unable to make an impact after replacing the starter in the 65th minute.
It was not for a lack of chance. The majority of the home side's offensive moves came through Grealish and the forward, who tirelessly whipped threatening balls into the Spurs penalty area.
What next for these two sides?
Everton: Moyes' men head to the Stadium of Light in the Premier League on Monday, 3 November at 20:00 GMT.
Tottenham: Spurs travel to Newcastle's ground on Wednesday, 29 October for their fourth-round Carabao Cup tie against Newcastle.